DEVOTE trial shows lower rates of severe hypoglycaemia are associated with reduced risk of death

A new post-hoc analyses from the DEVOTE trial showing that people with type 2 diabetes at high risk of cardiovascular disease who experience severe hypoglycaemia are at greater risk of death. The risk was four-fold higher (2.78 events/100 patient-years vs 11.23 events/100 patient-years) 15 days after an event and two and a half-fold higher (2.64 events/100 patient-years vs 7.32 events/100 patient-years) anytime following an episode of severe hypoglycemia. In addition, results also showed that daily fluctuations in blood glucose levels in people with type 2 diabetes at high risk of cardiovascular disease are associated with a higher risk of death. The