Researchers at the Sahlgrenska Academy have identified the genetic variations that are believed to cause osteoporosis. The study, published in Nature Genetics and involving leading researchers from Sweden and the world, shows that women with a higher proportion of genetic variations associated with osteoporosis have a more than 50% increased fracture risk. The researchers have now succeeded in identifying a total of 56 genetic regions that control bone density in human beings. Fourteen of these genetic variants increase the risk of fractures. Claes Ohlsson, a professor at the Sahlgrenska Academy said: “This is the first time anyone has identified the genetic variants that are so strongly associated with an increased risk of fracture.” The results have led to several new findings in bone biology, among other things the researchers identified several important molecular signalling pathways for bone density that can be targets for new treatment methods and therapies.