Hypertension: is it time to think about bedtime dosing?

Introduction Trial data Further work Conclusion References           Introduction Hypertension is estimated to account for up to 6% of deaths worldwide,1 and is the most commonly treated modifiable risk factor for cardiovascular disease (CVD). There is a clear relationship between reducing blood pressure for hypertensive patients and reduction in cardiovascular death and mortality, although this benefit may be attenuated with multi-morbidity and age.2 Recent clinical guidelines in the UK,3 and further afield,4 have recommended that a diagnosis of hypertension is made using ambulatory blood pressure monitoring (ABPM). Among the benefits of ABPM is the ability to