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Is adenosine the missing link in restless leg syndrome?

Researchers have identified a common mechanism implicating adenosine in the cause of restless leg syndrome (RLS) symptoms – the periodic limb movements characteristic of RLS and the state of enhanced arousal that both disrupt sleep.

Researchers have identified a common mechanism implicating adenosine in the cause of restless leg syndrome (RLS) symptoms – the periodic limb movements characteristic of RLS and the state of enhanced arousal that both disrupt sleep. Preclinical findings in a rat model of RLS and clinical results in humans together suggest that targeting the pathogenetic downregulation of adenosine A1 receptor (A1R) may be a promising therapeutic strategy, according to a new study. RLS is a common disorder, with about 5% of individuals in the US. and Europe reporting symptoms, as described in the article “The Adenosine Hypothesis of Restless Legs Syndrome”. More than

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