As part one outlined in the August issue (Vol 36:8), differential diagnosis of late-onset MS (LOMS) may be diffi cult and includes cerebro-spinal vascular syndromes, hypertension-related disorders, compressive myelopathies, primary or secondary vasculitis, metabolic diseases, degenerative and nutritional syndromes. In the second and final part of the series, Dr Nabil Aly discusses management and drug therapy treatments for LOMS.