Peripheral neuropathies are common in older people. Although the ageing process itself may play a part, there are multiple other causes. Peripheral neuropathy interferes with normal daily activities and leads to increased risk of falls, injury and poor quality of life. Management of peripheral neuropathy ofen needs a multidisciplinary team approach.

Siyum Strait, Specialist Registrar Acute Medicine, Great Western Hospital, Swindon

Pippa Medcalf, Consultant Physician, Gloucester Royal Hospital, Great Western Road, Gloucestershire

Email Pippa.Medcalf@glos.nhs.uk

Peripheral neuropathy is one pattern of damage to the peripheral nervous system.1 Physical signs of peripheral neuropathy are common in older people.2 Recognition of these deficits is particularly important because peripheral neuropathy may contribute to the vulnerability to falls that is common in this age group.3,4 More than 30% of patients aged over 65 years will fall at least once per year.5 Peripheral neuropathy commonly causes impairment of proprioception and balance, which can be identified from an inability to maintain unipedal stance for 10 seconds, impaired position sense at the great toe and decreased vibratory sense that improves proximally.6 Recognition of the cohort of patients with these deficits may identify treatable causes and provide a better management plan for patients prone to falling.6,7

Classifcation

Peripheral neuropathy can be classifed by the pattern of nerve involvement, time course, type of defcit or nature of the underlying pathology.8 (Box 1) The patterns of nerve involvement that occur include mononeuropathy, multiple mononeuropathy (mononeuritis multiplex), symmetrical polyneuropathy, radiculopathy and polyradiculoneuropathy. Mononeuropathy refers to involvement of major nerve trunks, singly or multiply. Radiculopathy refers to involvement of nerve roots, again singly or multiply. Polyneuropathy affects terminal branches of multiple nerves, often involving both legs and arms and occurring bilaterally (symmetrical polyneuropathy).9 Distal symmetrical polyneuropathy is the most common variety of polyneuropathy.10 Te time course can be acute (reaching maximal deficit in less than four weeks eg. Guillain-Barré syndrome), subacute (reaching maximal defcit in 4–8 weeks) or chronic (taking more than eight weeks to develop). Te resulting defcits may be purely or predominantly sensory (eg. diabetic distal symmetrical polyneuropathy ) , pure l y motor (eg. acute motor axonal neuropathy), mixed motor and sensory (eg. Charcot-Marie-Tooth disease) and autonomic. Te responsible pathology may be axonal, demyelinating or mixed axonal and demyelinating. Peripheral neuropathies of all groups may involve large nerve fbres, small nerve fbre or both. Large nerve fibres are long, myelinated and enable fast conduction of impulses. They can afect motor function and the sensory modalities of vibration, position sense and temperature. Small fbres may or may not be myelinated. Each type involves different sensations. Involvement of small fbres commonly produces pain and paresthesiae (often described as burning, lancinating or “ice pick in the bone”). Small fibre neuropathy is the most common type of neuropathy in people over the age of 50 years and typically affects the lower limbs. It often precedes the development of large fibre neuropathy. This type of neuropathy is ofen unrecognised by physicians and responds poorly or slowly to medication.9 Although large and small nerve fibres may be affected together, only large fibre involvement can be detected by conventional nerve conduction studies. Nerve damage due to inflammation or compression tends to sustain a more or less complete recovery because of the ability of Schwann cells to proliferate and remyelinate demyelinated axons.

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Causes

Among adult patients referred for assessment of peripheral neuropathy, a specifc cause can be identifed in about 72% cases.2

Mononeuropathy

Mononeuropathy is usually due to direct compression or entrapment of the nerves but may be the first manifestation of diabetic or vasculitic neuropathy. (Box 2)

Multiple mononeuropathy  

Multiple mononeuropathy (mononeuritis multiplex) is caused by vascular, infammatory, infltration, immune reactions and trauma. (Box 3)

Polyneuropathy

Causes of symmetrical polyneuropathy are more extensive and complicated than those of mononeuropathy, although relatively few diagnoses account for a large number of cases (eg. diabetes mellitus, alcohol over use).

Clinical evaluation

An accurate history and clinical examination remains vital in the clinical evaluation of a patient with peripheral neuropathy.

History

The history should address symptoms, possible causes and time course. It is important to note the time period that has taken for symptoms to evolve and progress. Sensory nerve involvement commonly causes a sensation of wearing an invisible glove or sock, burning or freezing pain in the extremities, numbness, tingling, pins and needles, bandlike sensation around the wrist or ankles and unsteadiness and stumbling. Motor symptoms are usually those of wasting and weakness. Te symptoms will depend upon the muscle groups affected and whether those involved are distal or proximal, but include difculty in turning keys in locks, unfastening buttons and removing the tops of bottles and jars, foot drop, difculty climbing stairs, getting out of chairs and standing from crouching. Patients may also have cramps and spasms. Autonomic symptoms depend upon the system involved. Cardiac involvement may give rise to heart rate irregularities, orthostatic hypotension and dizziness on standing. Gastro-intestinal involvement can commonly cause nausea, vomiting, constipation and diarrhoea. Genito-urinary involvement results in poor bladder control and sexual dysfunction. Autonomic symptoms can be very disabling. In searching for probable causative factors, enquiry should routinely address recent infections, alcohol and drug intake, diet, family history and symptoms of systemic disease.

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 Clinical examination  

Motor signs include muscle wasting and weakness, which in symmetrical polyneuropathy is usually distal and symmetrical. Occasionally fasciculation may occur, particularly in radiculopathy. Sensory loss is also predominantly distal, often in a glove and stocking distribution. Sensory testing should include light touch, pinprick, vibration and joint position. Distal tendon refexes are commonly absent. The patient should be observed standing and walking, rising onto their heels and toes, the Romberg’s test and walking heel to toe. The skin should be examined for trophic skin changes and ulcers in the extremities. Bony deformities such as pes cavus and clawtoes may be present. Nerves should be palpated for thickening. Examination of the optic fundus may reveal papilloedema in chronic inflammatory demyelinating polyneuropathy and the retinal abnormalities of diabetes mellitus.

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Investigations

The clinical features ofen suggest a likely underlying cause and point to the most appropriate investigations.11 General laboratory tests and nerve conduction studies should be performed as the first stage of investigation in all patients. Subsequent investigations will depend on the results of these initial studies.11

General laboratory tests

Basic laboratory investigations that should be performed on all patients with peripheral neuropathy of undetermined aetiology include urinalysis, haemoglobin, white cell count, platelets, erythrocyte sedimentation rate, fasting blood glucose, serum electrolytes, serum proteins, vitamin B12, TSH, auto antibodies, serum protein electrophoresis and immunoelectrophoresis, serum creatinine, liver function tests, chest radiographs and electrophysiological studies. If these investigations do not provide information that leads to a diagnosis, special investigations may be required, such as cryoglobulins, HIV, anti Myelin- Associated Glycoprotein (MAG) antibodies, urinary heavy metals and Lyme serology.

Nerve conduction studies

Nerve conduction studies play a vital role in confirming the presence of peripheral neuropathy and establishing its cause. Tey help to determine whether a patient has a mononeuropathy, mononeuritis multiplex or a generalised neuropathy; whether the neuropathy is symmetrical or asymmetrical; whether both sensory and motor fibres are affected; and whether the underlying pathology is of axonal degeneration or demyelination. Motor conduction velocities below 40m/s in the upper limb and 30m/s in the lower limb indicate possible demyelination. Lesser degrees of slowing of nerve conduction velocity indicate peripheral nerve damage, which could be due to axonal loss as in axonal neuropathy or neuronopathy (pathology within the nerve cell body).

Needle electromyography

Electromyography is ofen useful in confirming the presence of axonal degeneration. However, denervation potentials may not appear until three weeks afer the onset of axonal degeneration.

Examination of cerebrospinal fluid

Cerebrospinal fluid (CSF) examination is sometimes useful in the investigation of peripheral neuropathy. For example, in Guillain-Barré syndrome, CSF protein concentration rises in the frst week. In chronic infammatory demyelinating polyneuropathy, oligoclonal IgG bands may be present. An increase in white cell count may be seen in HIV and Lyme disease.

Other specialised investigations

Quantitative sensory testing, autonomic function studies, molecular genetics and nerve biopsy (eg. sural) are some of the targeted investigations. However, these are not routinely done and may need referral to a specialised unit for further assessment.

Management

Management of polyneuropathy depends on the underlying cause and its clinical presentations and implications. Identifcation of the cause of the peripheral neuropathy often leads to useful treatment even if it is only the removal of the causative agent (eg. stopping alcohol) or treatment of the underlying condition (eg. diabetes, B12 defciency, HIV, Lyme disease).8 It is important to identify the impact of peripheral neuropathy on a patient’s wellbeing. Aspects commonly missed in evaluation and management include anxiety and depression, breakdown of social relationships and activities of daily life, sleep disturbances, inability to engage in recreational activities and negative feelings of self-worth. O c c u p a t i o n a l a n d physiotherapy, as well as psychosocial support, may reduce the impact of these factors. Preservation of physical functions and maintenance of quality of life should be a priority in the management of peripheral neuropathy. Neuropathic pain due to small fbre neuropathy tends not to respond well to treatment.12 However, some benefit may be obtained by the use of drugs, such as tricyclic anti-depressants (eg. amitriptyline, dosulepin); antiepileptics (eg. sodium valproate, carbamazepine), selective serotonin reuptake inhibitors (SSRI), narcotic analgesics (eg. opiates) and topical agents (eg. capsaicin, lidocaine patches). Nerve blocks and local anaesthetics may be used as a last resort to alleviate otherwise intractable pain.

Common neuropathies in older people  

The older person is more likely to succumb to peripheral neuropathy related to diabetes, paraproteinaemia-associated malignancies and chronic inflammatory neuropathies (eg. chronic inflammatory demyelinating polyneuropathy).

Diabetic polyneuropathy

Distal symmetric polyneuropathy is the most common form of diabetic neuropathy.13 The duration and severity of hyperglycaemia, presence of dyslipidemia, hypertension and smoking are major risk factors for the development of diabetic polyneuropathy. Diabetic polyneuropathy is primarily a distal, symmetrical sensory neuropathy. Sensory loss typically ascends from the peripheries in a “glove-stocking” pattern. This pattern reflects damage according to axon length, with the longest axons being afected frst. Motor involvement is sometimes observed, but only later and in more severe cases. Te clinical signs are loss of vibratory sense and proprioception refecting large fibre loss. The small fibre loss gives rise to impairment of pain, light touch and temperature. Reduced or absent ankle refexes occur early, but widespread loss of reflexes and motor weakness are late fndings. Diabetic dermopathy may occur as a manifestation of diabetic polyneuropathy in older patients. Diabetic polyneuropathy is a very significant risk factor for diabetic foot ulcers and a major reason for poor healing in such ulcers. Diabetic polyneuropathy also contributes to problems with gait and balance, falls and fear of falling.14 Specifically, it can cause postural instability, loss of ankle strength and diminished proprioception. In the UK, diagnosis of diabetic polyneuropathy is based on a twopart diagnostic test, consisting of a symptom score and a physical examination score.15 Peripheral neuropathy is considered to be present if there are moderate or severe signs (≥ 6 points), even in the absence of symptoms, or if there are at least mild signs (≥3 points) in the presence of moderate symptoms (≥5 points). A neurologic sign score of eight or more indicates that the patient’s feet are at high risk for ulceration. The management of diabetic polyneuropathy has three main elements: glycaemic control, foot care and treatment of pain. Glycaemic control is the most important factor in the prevention and progression of diabetic polyneuropathy. For optimal foot care, patients should be educated to inspect their feet on a daily basis to look for dry or cracking skin, fissures, plantar callus formation and signs of early infection between the toes and around the toe nails. Fortunately, only a minority of patients with diabetic polyneuropathy will develop painful symptoms and sometimes pain symptoms may resolve spontaneously. In other cases, pain control may be achieved using one or more of the drugs described earlier under “management.”

Chronic inflammatory demyelinating polyneuropathy

Chronic inflammatory demyelinating polyneuropathy is the commonest acquired cause of chronic demyelinating neuropathy and typically causes symmetrical weakness and sensory changes in the limbs, developing over a period of more than eight weeks. It is important to distinguish chronic inflammatory demyelinating polyneuropathy from chronic axonal neuropathy, because the former, unlike the latter, responds well to treatment. Te diagnosis is suggested by a history of a relapsing course, examination findings of proximal or distal weakness, and CSF findings of increased CSF protein with normal cell count.8 Confrmation of the diagnosis depends on neurophysiological studies showing slowing of nerve conduction. Corticosteriods, intravenous immunoglobulin (IVIg) and plasma exchange have all been found to be benefcial in treatment. However, sometimes, in pure motor chronic inflammatory demyelinating polyneuropathy, symptoms worsen on corticosteroids so IVIg should be the frst line of treatment. The usual regime for treatment of chronic infammatory demyelinating polyneuropathy with IVIg is infusion repeated every four weeks until maximum response is achieved. If the response to corticosteriods, IVIg and/or plasma exchange is poor, cytotoxic drugs can be used. At present, azathioprine is the commonest such drug in use in this situation.

Paraproteinemic neuropathies

Monoclonal gammopathy is a common disorder, especially in older age. A small percentage of these patients will develop overt multiple myeloma.16 Paraproteins may be associated with axonal neuropathy, amyloid light (AL) chain amyloid neuropathy and demyelinating neuropathy.8 Monoclonal gammopathy of undetermined significance (MGUS), solitary myeloma or plasmacytoma and POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein band on electrophoresis, skin hyperpigmentation) syndrome can be associated with demyelinating neuropathy.8 Te clinical picture is usually of a very slowly progressive sensory or sensory and motor demyelinating neuropathy. Ofen there is a postural tremor. The pathophysiology seems to be one of sharing the same epitope of IgM MGUS and antibodies to Myelin- Associated Glycoprotein (MAG) and other myelin proteins and glycolipids. Testing for anti-MAG antibodies is widely available. Te nerve conduction studies show a prolonged distal motor latency. Te need for treatment in these neuropathies is debatable because they progress only very slowly. If necessary, cytotoxic drugs, such as chlorambucil, can be used.

Conclusion

Peripheral neuropathies commonly affect older people. Peripheral neuropathy can be caused by axonal damage or demyelination, as well as damage to large or small fbres. The risk of falls and disabling symptoms like pain are quite pronounced in the elderly, leading to poor quality of life. Diabetes and heavy alcohol use commonly cause symmetrical axonal polyneuropathies. Neurophysiological studies are helpful in distinguishing axonal from demyelinating neuropathies. However, in the presence of small fbre neuropathy, these tests ofen are not useful. Usually, there are no specific treatments available. A multidisciplinary approach with pain relief, physiotherapy, management of anxiety and depression are important in managing these patients.

Conflict of interest: none declared.

References available on online version at www. gmjournal.co.uk