Prostate cancer has overtaken lung cancer to become the most commonly occurring cancer in men in the Western world. In part one (GM October, 2006) of this two-part series, Drs Nishi Gupta, Heather Payne, Omar Al Salihi and David Gillatt discussed the structure of a multidisciplinary approach and some of the new management tools available to provide the best treatment for patients. They conclude the series by discussing best clinical management.