A new study has suggested that statins are ineffective at lowering cholesterol to target levels in more than half of patients and a more tailored approach is needed. 

The research by primary care experts at The University of Nottingham, which is published in Heart, found that 51.2% of patients prescribed statins saw little benefit to their cholesterol levels within two years, leading to a significant risk of developing cardiovascular disease in the future.

However, the researchers also revealed a significant therapeutic effect for the other 48.8% - statins in this group of patients were not only successful in lowering cholesterol by at least 40% but were more successful in preventing heart attack, stroke and narrowing of the arteries.

Compliance to the medication could be a factor but this was not studied in great detail. As a result, the authors urged patients not to stop taking their medication.

Dr Stephen Weng, Assistant Professor in Integrated Epidemiology and Data Science, in the University’s Division of Primary Care, led the study with GP researchers.

He said: “Our research has shown that in almost half of patients prescribed statins they are very effective and offer significant protection against cardiovascular disease.

“However, for the other half - whether it’s due to your genetic make-up, having side effects, sticking to the treatment, or other medications – we don’t see that intended benefit.

“We have to develop better ways to understand differences between patients and how we can tailor more effective treatment for those millions of patients who are simply blanket prescribed statins.”

The study looked at the data of more than 165,400 GP patients from the UK Clinical Practice Research Datalink system who had previously been unaffected by CVD before being prescribed statins.

Dr Ralph Akyea, a NIHR-SPCR funded PhD student who conducted the analysis, said: “Based on current national guidelines, a less than 40%% reduction in the level of bad cholesterol after two years of taking statins was considered ineffective. Our study revealed that 84,609 (51.2%) had a poor response to the statin treatment and, as a result, many people remained at a much higher risk of CVD caused by a build-up of plaque in their arteries.”

Other factors including the patient’s sex, age, weight, or other conditions have been reported to contribute to the variation in the success of statins reducing bad cholesterol, but the impact is considered by doctors to be modest.

It’s thought that genetic factors and patients not sticking to their medication may be an important explanation for this phenomenon.

Previous studies have looked at statin use but differences in the way the studies were designed and their data make it difficult to compare what they mean.


The Nottingham team are calling for further research into the issue and said that doctors need new tools to help predict patients’ cholesterol response to statins and other drugs. This could help tailor treatments and ensure the best possible outcomes for patients.