Ten traits predicted future asthma attacks, and the strongest were: being prone to exacerbations, depression, inhaler device polypharmacy, vocal cord dysfunction, and obstructive sleep apnoea.

The findings may help clinicians develop individualised management strategies for patients with severe asthma.

"We report the higher burden experienced by patients with severe asthma compared to non-severe and importantly identify which treatable traits are predictive of future asthma attacks. This highlights the usefulness of the treatable traits approach in severe asthma and identifies important targets for treatment," said lead author Dr Vanessa McDonald, of the University of Newcastle.